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edit growth differentiation factor 1 Identifiers Symbol GDF1 External IDs OMIM: 602880 MGI: 95683 HomoloGene: 105644 GeneCards: GDF1 Gene Gene Ontology Molecular function • growth factor activity • cytokine activity Cellular component • extracellular space • extracellular region Biological process • growth Sources: Amigo / QuickGO Orthologs Species Human Mouse Entrez 2657 14559 Ensembl ENSG00000130283 ENSMUSG00000055694 UniProt P27539 P20863 RefSeq (mRNA) NM_001492 NM_008107 RefSeq (protein) NP_001483 NP_032133 Location (UCSC) Chr 19: 18.84 - 18.87 Mb Chr 8: 72.84 - 72.86 Mb PubMed search [1] [2] Growth differentiation factor-1 (GDF1) is a protein that in humans is encoded by the GDF1 gene.[1] GDF1 belongs to the transforming growth factor beta superfamily that has a role in left-right patterning and mesoderm induction during embryonic development.[2] It is found in the brain, spinal cord and peripheral nerves of embryos.[1][2] References ^ a b Lee SJ (May 1991). "Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure". Proc. Natl. Acad. Sci. U.S.A. 88 (10): 4250–4. doi:10.1073/pnas.88.10.4250. PMID 2034669.  ^ a b Rankin CT, Bunton T, Lawler AM, Lee SJ (March 2000). "Regulation of left-right patterning in mice by growth/differentiation factor-1". Nat. Genet. 24 (3): 262–5. doi:10.1038/73472. PMID 10700179.  Further reading Jiang JC, Kirchman PA, Zagulski M, et al. (1998). "Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human.". Genome Res. 8 (12): 1259–72. PMID 9872981.  Lee SJ (1990). "Identification of a novel member (GDF-1) of the transforming growth factor-beta superfamily.". Mol. Endocrinol. 4 (7): 1034–40. doi:10.1210/mend-4-7-1034. PMID 1704486.  Li J, Jia H, Xie L, et al. (2009). "Correlation of inhibitor of differentiation 1 expression to tumor progression, poor differentiation and aggressive behaviors in cervical carcinoma.". Gynecol. Oncol. 114 (1): 89–93. doi:10.1016/j.ygyno.2009.03.016. PMID 19359031.  Ducy P, Karsenty G (2000). "The family of bone morphogenetic proteins.". Kidney Int. 57 (6): 2207–14. doi:10.1046/j.1523-1755.2000.00081.x. PMID 10844590.  Lee SJ (1991). "Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure.". Proc. Natl. Acad. Sci. U.S.A. 88 (10): 4250–4. doi:10.1073/pnas.88.10.4250. PMID 2034669.  Roessler E, Pei W, Ouspenskaia MV, et al. (2009). "Cumulative ligand activity of NODAL mutations and modifiers are linked to human heart defects and holoprosencephaly.". Mol. Genet. Metab. 98 (1-2): 225–34. doi:10.1016/j.ymgme.2009.05.005. PMID 19553149.  Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.  Karkera JD, Lee JS, Roessler E, et al. (2007). "Loss-of-function mutations in growth differentiation factor-1 (GDF1) are associated with congenital heart defects in humans.". Am. J. Hum. Genet. 81 (5): 987–94. doi:10.1086/522890. PMID 17924340.  Polymeropoulos MH, Xiao H, Sikela JM, et al. (1993). "Chromosomal distribution of 320 genes from a brain cDNA library.". Nat. Genet. 4 (4): 381–6. doi:10.1038/ng0893-381. PMID 8401586.  This article on a gene on chromosome 19 is a stub. You can help Wikipedia by expanding it. v • d • e v • d • e Cell signaling: TGF beta signaling pathway TGF beta superfamily of ligands TGF beta family (TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other (Activin and inhibin, Anti-müllerian hormone, Nodal) TGF beta receptors (Activin, BMP) TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) · ACVRL1 · BMPR1 (BMPR1A · BMPR1B) TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) · AMHR2 · BMPR2 TGFBR3: betaglycan Transducers/SMAD R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) · I-SMAD (SMAD6, SMAD7) · SMAD4 Ligand inhibitors Cerberus · Chordin · DAN · Decorin · Follistatin · Gremlin · Lefty · LTBP1 · Noggin · THBS1 Coreceptors BAMBI · Cripto Other SARA B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)