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This article is an orphan, as few or no other articles link to it. Please introduce links to this page from related articles; suggestions may be available. (February 2009) edit SET and MYND domain containing 3 Identifiers Symbols SMYD3; FLJ21080; KMT3E; MGC104324; ZMYND1; ZNFN3A1; bA74P14.1 External IDs OMIM: 608783 MGI: 1916976 HomoloGene: 41491 GeneCards: SMYD3 Gene EC number 2.1.1.43 Gene Ontology Molecular function • protein binding • methyltransferase activity • zinc ion binding • transferase activity • histone-lysine N-methyltransferase activity • metal ion binding Cellular component • nucleus • cytoplasm Biological process • chromatin modification • histone lysine methylation Sources: Amigo / QuickGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 64754 69726 Ensembl ENSG00000185420 ENSMUSG00000055067 UniProt Q9H7B4 Q3TIF7 RefSeq (mRNA) NM_001167740.1 NM_027188.3 RefSeq (protein) NP_001161212.1 NP_081464.1 Location (UCSC) Chr 1: 245.91 - 246.67 Mb Chr 1: 180.88 - 181.45 Mb PubMed search [1] [2] SET and MYND domain-containing protein 3 is a protein that in humans is encoded by the SMYD3 gene.[1] SMYD3 is a histone methyltransferase that plays a role in transcriptional regulation as a member of an RNA polymerase complex.[supplied by OMIM][1] Interactions SMYD3 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1[2] and POLR2A.[2] References ^ a b "Entrez Gene: SMYD3 SET and MYND domain containing 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64754.  ^ a b Hamamoto, Ryuji; Furukawa Yoichi, Morita Masashi, Iimura Yuko, Silva Fabio Pittella, Li Meihua, Yagyu Ryuichiro, Nakamura Yusuke (Aug. 2004). "SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells". Nat. Cell Biol. (England) 6 (8): 731–40. doi:10.1038/ncb1151. ISSN 1465-7392. PMID 15235609.  Further reading Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.  Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.  Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  Hamamoto R, Furukawa Y, Morita M, et al. (2004). "SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells". Nat. Cell Biol. 6 (8): 731–40. doi:10.1038/ncb1151. PMID 15235609.  Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.  Zhou Z, Ren X, Huang X, et al. (2006). "SMYD3-NY, a novel SMYD3 mRNA transcript variant, may have a role in human spermatogenesis". Ann. Clin. Lab. Sci. 35 (3): 270–7. PMID 16081583.  Tsuge M, Hamamoto R, Silva FP, et al. (2005). "A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers". Nat. Genet. 37 (10): 1104–7. doi:10.1038/ng1638. PMID 16155568.  Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  Hamamoto R, Silva FP, Tsuge M, et al. (2006). "Enhanced SMYD3 expression is essential for the growth of breast cancer cells". Cancer Sci. 97 (2): 113–8. doi:10.1111/j.1349-7006.2006.00146.x. PMID 16441421.  Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.  Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.  Wang XQ, Miao X, Cai Q, et al. (2007). "SMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population". Exp. Oncol. 29 (1): 71–3. PMID 17431393.  This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.v · d · e